Griffithsin patent

Author: rqnm

August undefined, 2024

WebA safe and effective topical microbicide against HIV is urgently needed to prevent sexual transmission. Hence, we evaluated griffithsin (GRFT), a 12.7 kDa carbohydrate-binding … WebJul 8, 2024 · The patent rights for this technology cover the sequence of the GRFT polypeptide as well as several GRFT variants mutated to render them glycosylation …

US11339195B2 - Griffithsin mutants - Google Patents

WebInterPro. Griffithsin is a protein isolated from the red algae Griffithsia. It has a 121- amino acid sequence [2] which exhibits a Jacalin-like lectin fold. Several structures of this … WebPatent Application No. 63/026,375 described above, as well as a second U.S. Provisional Patent Application No. 63/070,375 entitled “Q-Griffithsin Nasal Spray,” (HHS Ref. No. E-029-2024-1-US-01), filed on August 26, 2024. The Government of the United States is not a co-owner on this second US Provisional Patent Application, and it is therefore, new time maceio

(12) United States Patent (10) Patent No.: US 8,088,729 B2 …

WebFeb 7, 2011 · US Patent for Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use Patent (Patent # 8,394,764 issued March 12, 2013) - Justia Patents Search WebThe invention relates to an anti-viral Griffithsin polypep tide related conjugates, compositions, nucleic acids, vectors, host cells, antibodies, and methods for their production and SC. BACKGROUND OF THE INVENTION WebGriffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development and regulatory … new time look

Griffithsin, a potent HIV entry inhibitor, is an excellent

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WebJul 25, 2024 · Griffithsin, or "GRFT", is an investigational product that is being developed as a microbicide. GRFT is a naturally occurring protein originally isolated from the red alga Griffithsia found in the South Pacific Ocean. GRFT is one of the most powerful, broad-spectrum antivirals ever tested and its activity is under study for potential ... WebU.S. Patent Application 20240087359 for Griffithsin Mutants Griffithsin Mutants O'Keefe; Barry R. ; et al. [The United States of America,as represented by the Secretary,Department of Health and Human Services] midwest ambulance service inc ohioWebThe results show that griffithsin is potently active (sub-nanomolar EC 50 values) against a broad range of HIV isolates including T-tropic viruses (utilizing CCR5 as a co-receptor) and M-tropic viruses (utilizing CXCR4 as a co-receptor). This picomolar level of activity is more potent than that described for most of the current anti-HIV agents utilized in therapy or in … new timely factory building

"WebJan 6, 2024 · This is a phase 1 study for intranasal application of Q-Griffithsin (Q-GRFT) spray as a prophylactic for severe acute respiratory syndrome-CoV-2. This randomized, placebo-controlled, single site will assess the local and systemic safety of intranasal Q-GRFT after 14 doses in approximately 45 adult participants. " - Griffithsin patent

Griffithsin patent

Griffithsin, glycosylation-resistant griffithsin, and related ...

WebJul 19, 2024 · The formulations for Q-griffithsin were originally developed as a possible preventative for HIV. However, after watching the COVID-19 pandemic escalate, the research team looked back at previous... WebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently under development as an anti-HIV microbicide.

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Webgriffithsin cov sars protein infection Prior art date 2024-08-24 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Pending Application number CN202410867243.0A Other languages English (en) Inventor ... WebUS8394764B2 - Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use - Google...

Webparticular molecule carries no net electrical charge) of the modified griffithsin polypeptides can optimize the bioavailability of the modified griffithsin polypeptides in different … WebGriffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red ...

Webgriffithsin viral virus polypeptide hiv Prior art date 2004-06-01 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal … WebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently …

Webparticular molecule carries no net electrical charge) of the modified griffithsin polypeptides can optimize the bioavailability of the modified griffithsin polypeptides in different compartments of the body (e.g., nasal cavity, lung, gut, small intestine, colon, blood, vagina, and rectum). The pH of wild-type griffithsin of SEQ ID NO: 2 is 5.1.

WebNov 16, 2024 · Detailed Description: Q-Griffithsin (Q-GRFT) nasal spray is an investigational product that has broad spectrum antiviral activity. Q-GRFT is derived from … new time investmentWebUS11339195B2 2024-05-24 Griffithsin mutants. US8394764B2 2013-03-12 Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, … new timelinemaxWebJul 14, 2024 · A “Swiss army knife” protein that is active against several viruses may also offer some protection against Nipah virus, a lethal pathogen with no cure or vaccine. The “tool” is griffithsin, a compound extracted from the red algae Griffithsia. A modified version of the protein substantially increased survival rates when administered as a preventative … new_time loop- timeWebOct 24, 2016 · Abstract. Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a … new timeless where is the loveWebThis technology describes the lectin, Griffithsin (GRFT), isolated from red algae. GRFT shows significant broad-spectrum anti-viral activity making it a promising agent for use as … new timeline idaho murdersWebOct 6, 2024 · Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for … new timeline soul calibur 6WebNov 4, 2024 · Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) … new timeline for moon 2024 nasa