Webb30 apr. 2016 · In this work, we have investigated the effects of two brain penetrant CK-1δ inhibitors (IGS-2.7 and IGS-3.27) designed and synthetized in our laboratory on cell … Webb2 feb. 2024 · Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin. Methods Cervical cancer cells were pre-treated with INI-43 before treatment with cisplatin, and MTT cell viability and apoptosis assays …
TDP-43, a protein central to amyotrophic lateral sclerosis, is ...
Webb15 dec. 2024 · A subset of Wnt-addicted cancers are sensitive to targeted therapies that block Wnt secretion or receptor engagement. RNF43 loss-of-function (LOF) mutations that increase cell surface Wnt receptor abundance cause sensitivity to Wnt inhibitors. However, it is not clear which of the clinically identified RNF43 mutations affect its function in vivo. WebbCytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death Highlights • Transient stress induces long-lasting phase separation of cytoplasmic TDP-43 • Formation/maintenance of phase separated TDP-43 is independent of stress granules • ta forsberg inc
TDP-43 Puts the STING in ALS - ScienceDirect
Webb15 sep. 2015 · TDP-43 is a RNA binding protein that is nuclear under basal conditions but translocates to the cytoplasm during stress where it forms cytoplasmic RNA/protein … Webb19 jan. 2024 · TDP-43 mitochondrial localization inhibitory peptide can also abolish cytoplasmic TDP-43 accumulation, restore mitochondrial function, prevent neuronal loss, and alleviate motor-coordinative and cognitive deficits in adult hemizygous TDP-43 M337V mice [ 35]. Targeting TDP-43 as a potential treatment for ALS Webb1 apr. 2024 · Deubiquitination enzyme UCH37 interacts with substrate proteins and then deubiquitinates substrates to inhibit their ubiquitination degradation in 19S regulatory … ta for hand washing